MEMORIA 2023 - Área 7. Biotecnología. Aplicaciones Sanitarias de Biociencias

Área 7. Biotecnología. Aplicaciones Sanitarias de Biociencias

OBJETIVOS CIENTÍFICOS VINCULADOS AL PLAN ESTRATÉGICO

Generar conocimiento científico de excelencia: se mantienen los indicadores del año pasado. Destacamos la mejora en liderazgo, incluido el liderazgo femenido de las publicaciones. Se incrementan levemente los indicadores cualitativos.
Captación de talento científico: Se ha conseguido dos nuevos recursos humanos competitivo. El número de investigadores también ha aumentado considerablemente gracias a la financiación competitiva y no competitiva de los grupos.
Dinamizar la captación de recursos: la captación de recursos se ha mantenido con respecto a años anteriores, aunque ha disminuido la financiación. No se han conseguido ingresos por investigación clínica.

11 Grupos de Investigación

BIOLOGÍA DE LA REPRODUCCIÓN (CONSOLIDADO)
BIOMEMBRANAS Y SEÑALIZACIÓN CELULAR (CONSOLIDADO)
BIOQUIMICA Y BIOTECNOLOGIA ENZIMATICA (CONSOLIDADO)
FISIOLOGÍA REPRODUCTIVA Y REPRODUCCIÓN ASISTIDA (CONSOLIDADO)
BIOLOGÍA MOLECULAR DE SISTEMAS (CONSOLIDADO)
INVESTIGACIÓN EN GINECOLOGÍA, REPRODUCCIÓN Y MEDICINA MATERNO-FETAL (CONSOLIDADO)
TECNOLOGÍAS DE MODELADO, PROCESAMIENTO Y GESTIÓN DEL CONOCIMIENTO (CONSOLIDADO)
GRUPO DE INVESTIGACIÓN EN RADIOLOGÍA (EMERGENTE)
GRUPO DE RADIOFARMACIA (CLÍNICO ASOCIADO)
GRUPO DE INVESTIGACIÓN EN FÍSICA MÉDICA (EMERGENTE)
FARMACOCINETICA CLINICA Y FARMACOTERAPIA APLICADA (CLÍNICO ASOCIADO)

INDICADORES GENERALES

Nº Publicaciones

213.8

Impacto Total

4.28

Impacto Medio

Tipo	Nº Pubs	FI total	FI Medio
Originales	48 (96.0%)	201.6	4.2
Revisiones	2 (4.0%)	12.2	6.1

76.0

Q1%

20.0

D1%

FI >= 15

Tipo	Nº Q1	Nº D1	Nº FI >= 15
Originales	36	9	0
Revisiones	2	1	0

INDICADORES DE LIDERAZGO

37 (74.0%)

Nº Publicaciones

165.7

Impacto Total

4.48

Impacto Medio

	Nº Pubs	FI total	FI Medio
Mujer	21 (56.76%)	90.9	4.33
Hombre	16 (43.24%)	74.8	4.68

78.38

Q1%

21.62

D1%

FI >= 15

	Nº Q1	Nº D1	Nº FI >= 15
Mujer	16	4	0
Hombre	13	4	0

OTROS INDICADORES

14.15

HCP10% (2019-2023)

77.78

HCP10 Liderado% (2019-2023)

44.44

HCP10 Lid. Mujeres% (2019-2023)

1.13

Crown (2019-2023)

76.0

Open Access%

58.0

Col. International%

* Se muestran las 5 especies, los 10 genes y las 20 enfermedades más nombradas. Los valores están normalizados logarítmicamente en base al número de publicaciones.

INDICADORES EVOLUTIVOS

DESTACADAS

Cuenca-Guardiola J, de la Morena-Barrio B*, Garcia JL, ..., Fernandez-Breis JT*. Improvement of large copy number variant detection by whole genome nanopore sequencing. Journal of Advanced Research, 2023, 50, 145-158, PMID: 36323370, FI: 11.4

Martinez-Rodriguez P, Guerrero-Rubio MA, Hernandez-Garcia S, ..., Gandia-Herrero F*. Characterization of betalain-loaded liposomes and its bioactive potential in vivo after ingestion. Food Chemistry, 2023, 407, 135180, PMID: 36521390, FI: 8.5

Guerrero-Rubio MA, Walker-Hale N, Guo R, ..., Gandia-Herrero F* et al. Are seven amino acid substitutions sufficient to explain the evolution of high l-DOPA 4,5-dioxygenase activity leading to betalain pigmentation? Revisiting the gain-of-function mutants of Bean et al. (2018). New Phytologist, 2023, 239, 2265-2276, PMID: 37243529, FI: 8.3

Navarro-Orcajada S, Conesa I, Vidal-Sanchez FJ, ..., Lopez-Nicolas JM*. Stilbenes: Characterization, bioactivity, encapsulation and structural modifications. A review of their current limitations and promising approaches. Critical Reviews in Food Science and Nutrition, 2023, 63, 7269-7287, PMID: 35234546, FI: 7.3

Guerrero-Rubio MA, Hernandez-Garcia S, Garcia-Carmona F, Gandia-Herrero F*. Consumption of commonly used artificial food dyes increases activity and oxidative stress in the animal model Caenorhabditis elegans. Food Research International, 2023, 169, 112925, PMID: 37254351, FI: 7.0

LISTADO COMPLETO

Zapata-Perez R, Garcia-Saura AG, Scantlebery AML, ..., Sanchez-Ferrer A. Biotechnological production of reduced and oxidized NAD(+) precursors. Food Research International, 2023, 165, 112560, PMID: 36869544, FI: 7.0

Vinolas-Verges E, Ribas-Maynou J, Barranco I et al. Chromatin condensation but not DNA integrity of pig sperm is greater in the sperm-rich fraction. Journal of Animal Science and Biotechnology, 2023, 14, 139, PMID: 37926841, FI: 6.3

Barranco I, Sanchez-Lopez CM, Bucci D, ..., Roca J*. The Proteome of Large or Small Extracellular Vesicles in Pig Seminal Plasma Differs, Defining Sources and Biological Functions. Molecular & Cellular Proteomics, 2023, 22, 100514, PMID: 36796643, FI: 6.1

Gonzalez-Vidal A, Mercado-Saenz S, Burgos-Molina AM, ..., Alcaraz M* et al. Molecular Mechanisms of Resistance to Ionizing Radiation in S. cerevisiae and Its Relationship with Aging, Oxidative Stress, and Antioxidant Activity. Antioxidants, 2023, 12, PMID: 37759994, FI: 6.0

Lozano-Terol G, Gallego-Jara J, Sola-Martinez RA, ..., de Diego Puente T. Regulation of the pyrimidine biosynthetic pathway by lysine acetylation of E. coli OPRTase. Febs Journal, 2023, 290, 442-464, PMID: 35989594, FI: 5.5

Gavira JA, Rico-Jimenez M, Ortega A et al. Emergence of an Auxin Sensing Domain in Plant-Associated Bacteria. Mbio, 2023, , e0336322, PMID: 36602305, FI: 5.1

Henarejos-Escudero P, Mendez-Garcia FF, Hernandez-Garcia S, ..., Gandia-Herrero F*. Design, Synthesis and Gene Modulation Insights into Pigments Derived from Tryptophan-Betaxanthin, Which Act against Tumor Development in Caenorhabditis elegans. International Journal of Molecular Sciences, 2023, 25, PMID: 38203234, FI: 4.9

Angulo J, Fernandez A, Sevilleja-Ortiz A, Sanchez-Ferrer A et al. Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries. International Journal of Molecular Sciences, 2023, 24, PMID: 37686206, FI: 4.9

Parra A, Padilla L, Lucas X, ..., Roca J*. Seminal Extracellular Vesicles and Their Involvement in Male (In)Fertility: A Systematic Review. International Journal of Molecular Sciences, 2023, 24, PMID: 36902244, FI: 4.9

Navarro-Orcajada S, Vidal-Sanchez FJ, Conesa I, ..., Lopez-Nicolas JM*. Improvement of the Physicochemical Limitations of Rhapontigenin, a Cytotoxic Analogue of Resveratrol against Colon Cancer. Biomolecules, 2023, 13, PMID: 37627335, FI: 4.8

Cerna-Vargas JP, Sanchez-Romera B, Matilla MA, Ortega A et al. Sensing preferences for prokaryotic solute binding protein families. Microbial Biotechnology, 2023, 16, 1823-1833, PMID: 37547952, FI: 4.8

Cuenca-Guardiola J, Morena-Barrio B, Navarro-Manzano E, ..., Corral J*, Fernandez-Breis JT*. Detection and annotation of transposable element insertions and deletions on the human genome using nanopore sequencing. Iscience, 2023, 26, 108214, PMID: 37953943, FI: 4.6

Toledo-Guardiola SM, Luongo C, Abril-Parreno L, ..., Matas C*. Different seminal ejaculated fractions in artificial insemination condition the protein cargo of oviductal and uterine extracellular vesicles in pig. Frontiers in Cell and Developmental Biology, 2023, 11, 1231755, PMID: 37868907, FI: 4.6

Belda-Perez R, Heras S, Cimini C, ..., Coy P*. Advancing bovine in vitro fertilization through 3D printing: the effect of the 3D printed materials. Frontiers in Bioengineering and Biotechnology, 2023, 11, 1260886, PMID: 37929185, FI: 4.3

Asensio Ruiz MA, Alonso Garcia A, Bravo-Ferrer Moreno ML, ..., Martinez Martinez T. In Vitro Hemocompatibility and Genotoxicity Evaluation of Dual-Labeled [(99m)Tc]Tc-FITC-Silk Fibroin Nanoparticles for Biomedical Applications. Pharmaceuticals, 2023, 16, PMID: 37259395, FI: 4.3

Minig L, Gracia Segovia M, Arencibia O, ..., Niguez I, ... et al. Oncological outcomes among young women with non-epithelial ovarian cancer: the YOC-Care study (Young Ovarian Cancer - Care). International Journal of Gynecological Cancer, 2023, ijgc-2022-004162 [pii], PMID: 36796862, FI: 4.1

Alcantud R, Weiss J, Terry MI, ..., Fernandez-Breis JT et al. Flower transcriptional response to long term hot and cold environments in Antirrhinum majus. Frontiers in Plant Science, 2023, 14, 1120183, PMID: 36778675, FI: 4.1

Castell-Diaz J*, Minarro-Gimenez JA, Martinez-Costa C*. Supporting SNOMED CT postcoordination with knowledge graph embeddings. Journal of Biomedical Informatics, 2023, 139, 104297, PMID: 36736448, FI: 4.0

Abril-Parreno L, Carthy TR, Keogh K et al. Genome-wide association study reveals candidate markers related to field fertility and semen quality traits in Holstein-Friesian bulls. Animal, 2023, 17, 100841, PMID: 37224615, FI: 4.0

Navarro-Orcajada S, Vidal-Sanchez FJ, Conesa I, ..., Lopez-Nicolas JM*. Antiproliferative Effects in Colorectal Cancer and Stabilisation in Cyclodextrins of the Phytoalexin Isorhapontigenin. Biomedicines, 2023, 11, PMID: 38002023, FI: 3.9

Canha-Gouveia A, Perez-Prieto I, Rodriguez CM et al. The female upper reproductive tract harbors endogenous microbial profiles. Frontiers in Endocrinology, 2023, 14, 1096050, PMID: 37415669, FI: 3.9

Alvarez-Rodriguez M, Roca J, Martinez EA et al. Mating modifies the expression of crucial oxidative-reductive transcripts in the pig oviductal sperm reservoir: is the female ensuring sperm survival? Frontiers in Endocrinology, 2023, 14, 1042176, PMID: 37351104, FI: 3.9

Luongo C, Llamas-Lopez PJ, Garrappa G, ..., Garcia-Vazquez FA*. Impact of inclusion of post-spermatic ejaculate fraction in boar seminal doses on sperm metabolism, quality, and interaction with uterine fluid. Scientific Reports, 2023, 13, 15258, PMID: 37709904, FI: 3.8

Sola-Martinez RA, Zeng J, Awchi M et al. Preservation of exhaled breath samples for analysis by off-line SESI-HRMS: proof-of-concept study. Journal of Breath Research, 2023, 18, PMID: 38029449, FI: 3.7

Abril-Parreno L, Druart X, Fair S et al. Metabolic signature of cervical mucus in ewe breeds with divergent cervical sperm transport: a focus on metabolites involved in amino acid metabolism. Metabolomics, 2023, 19, 59, PMID: 37338596, FI: 3.5

Pan R, Garcia-Diaz JA, Garcia-Sanchez F, Valencia-Garcia R*. Evaluation of transformer models for financial targeted sentiment analysis in Spanish. Peerj Computer Science, 2023, 9, e1377, PMID: 37346571, FI: 3.5

Abad-Navarro F, Martinez-Costa C, Fernandez-Breis JT*. HURON: A Quantitative Framework for Assessing Human Readability in Ontologies Ieee Access, 2023, 11, PMID: null, FI: 3.4

Garcia-Diaz JA, Garcia-Sanchez F, Valencia-Garcia R*. Smart Analysis of Economics Sentiment in Spanish Based on Linguistic Features and Transformers Ieee Access, 2023, 11, PMID: null, FI: 3.4

Gonzalez-Lopez A*. Improving input contrast estimation to an x-ray imaging system. Physics in Medicine and Biology, 2023, 10.1088/1361-6560/ad0534 [doi], PMID: 37857333, FI: 3.3

Gonzalez-Lopez A*. Technical note: Characteristics of the energy spread kernels of scattered radiation in an x-ray room. Medical Physics, 2023, 50, 643-650, PMID: 35908179, FI: 3.2

Parrilla I, Cambra JM, Cuello C, ..., Gil MA*, Martinez EA. Cryopreservation of highly extended pig spermatozoa remodels its proteome and counteracts polyspermic fertilization in vitro. Andrology, 2023, 10.1111/andr.13575 [doi], PMID: 38131448, FI: 3.2

Illueca Fernandez E, Fernandez Llatas C, Jara Valera AJ, Fernandez Breis JT et al. Sequence-oriented sensitive analysis for PM2.5 exposure and risk assessment using interactive process mining. Plos one, 2023, 18, e0290372, PMID: 37616197, FI: 2.9

Pineiro-Silva C, Navarro-Serna S, Belda-Perez R, Gadea J*. Production of Genetically Modified Porcine Embryos via Lipofection of Zona-Pellucida-Intact Oocytes Using the CRISPR/Cas9 System. Animals, 2023, 13, PMID: 36766231, FI: 2.7

Ramirez-Gonzalez D, Poto A, Peinado B, ..., Ruiz S*. Ultrasonography of Pregnancy in Murciano-Granadina Goat Breed: Fetal Growth Indices and Umbilical Artery Doppler Parameters. Animals, 2023, 13, PMID: 36830405, FI: 2.7

Gonzalez-Ramiro H, Gil MA, Cuello C, ..., Parrilla I*, ..., Martinez EA. The Use of a Brief Synchronization Treatment after Weaning, Combined with Superovulation, Has Moderate Effects on the Gene Expression of Surviving Pig Blastocysts. Animals, 2023, 13, PMID: 37174605, FI: 2.7

Padilla L, Barranco I, Martinez-Hernandez J, ..., Pastor LM et al. Extracellular vesicles would be involved in the release and delivery of seminal TGF-beta isoforms in pigs. Frontiers in Veterinary Science, 2023, 10, 1102049, PMID: 36846267, FI: 2.6

Monteagudo-Cascales E, Ortega A, Velando F et al. Study of NIT domain-containing chemoreceptors from two global phytopathogens and identification of NIT domains in eukaryotes. Molecular Microbiology, 2023, 119, 739-751, PMID: 37186477, FI: 2.6

Cortes-Sandoval S, Seco-Rovira V*, Beltran-Frutos E, ..., Pastor LM*. Heterogeneity of mesenchymal cells in human amniotic membrane at term. Histology and Histopathology, 2023, , 18660, PMID: 37721417, FI: 2.5

Parraga-Ros E, Alvarez-Martin U, Seva J, ..., Romar R*. The impact of in vitro embryo production on placental and umbilical cord vascularization is minimized by the addition of reproductive fluids. Theriogenology, 2023, 208, 149-157, PMID: 37329589, FI: 2.4

Stiavnicka M, Hosek P, Abril-Parreno L et al. Membrane remodulation and hyperactivation are impaired in frozen-thawed sperm of low-fertility bulls. Theriogenology, 2023, 195, 115-121, PMID: 36332370, FI: 2.4

Gonzalez-Plaza A, Cambra JM, Garcia-Canovas M, ..., Martinez CA*, Cuello C. Cryotop vitrification of large batches of pig embryos simultaneously provides excellent postwarming survival rates and minimal interference with gene expression. Theriogenology, 2023, 206, 1-10, PMID: 37148716, FI: 2.4

Diaz LS, Navalon CI, Espin RG et al. Impact of proactive of infliximab monitoring using the Bayesian approach in the maintenance phase in patients with inflammatory bowel disease. Gastroenterologia y Hepatologia, 2023, 46, 504-511, PMID: 36400260, FI: 2.2

Serrano Diaz L, Iniesta Navalon C, Gomez Espin R, ..., Bernal Morell E et al. Comparative effectiveness and drug survival of biosimilar infliximab CPT-13 vs. reference infliximab in inflammatory bowel disease: A retrospective cohort study. Gastroenterologia y Hepatologia, 2023, S0210-5705(23)00392-8 [pii], PMID: 37597745, FI: 2.2

Garcia C, Prieto MT, Escudero F, ..., De Paco Matallana C. The impact of early versus delayed cord clamping on hematological and cardiovascular changes in preterm newborns between 24 and 34 weeks' gestation: a randomized clinical trial. Archives of Gynecology and Obstetrics, 2023, 10.1007/s00404-023-07119-0 [doi], PMID: 37436461, FI: 2.1

Canha-Gouveia A, Di Nisio V, Salumets A et al. The Upper Reproductive System Microbiome: Evidence beyond the Uterus. Seminars in Reproductive Medicine, 2023, 41, 190-199, PMID: 38320577, FI: 1.9

AYUDAS CONCEDIDAS EN 2023

TOTAL DE AYUDAS CONCEDIDAS

Nº Ayudas

0.85M €

Financiación

TOTAL DE AYUDAS RECURSOS HUMANOS CONCEDIDAS

Nº Ayudas

0.11M €

Financiación

TOTAL DE AYUDAS PROYECTOS I+D+i CONCEDIDAS

Nº Ayudas Europeas

0.0M €

Financiación Europea

Nº Ayudas Nacionales

0.49M €

Financiación Nacional

Nº Ayudas Regionales

0.25M €

Financiación Regional

TOTAL DE REDES CONCEDIDAS

Nº Ayudas

0.0M €

Financiación

OTRAS AYUDAS COMPETITIVAS CONCEDIDAS (MOVILIDAD, ORGANIZACIÓN DE EVENTOS CIENTÍFICOS, ...)

Nº Ayudas

0.0K €

Financiación

PROYECTOS DE I+D+i Y AYUDAS DE RRHH ACTIVAS EN 2023

TOTAL AYUDAS

RECURSOS HUMANOS

REDES

PROYECTOS INTERNACIONALES

PROYECTOS NACIONALES

PROYECTOS REGIONALES

INICIADA EN 2023

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

ACTIVOS EN 2023

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

FACTURACIÓN EN 2023

0.26M €

Facturado

Nº Tesis (0 con mención internacional)