MEMORIA 2023 - Área 1. Hematología y Oncología Clínico

Área 1. Hematología y Oncología Clínico - Experimental. Genética Clínica

OBJETIVOS CIENTÍFICOS VINCULADOS AL PLAN ESTRATÉGICO

Generar conocimiento científico de excelencia: se mantienen los datos con respecto al año anterior con algunos indicadores que bajan o suben mínimamente. La mejora más notable es en el porcentaje de primeros deciles que sube casi ocho puntos. Queremos destacar el aumento significativo en el liderazgo femenino en las publicaciones del área.
Captación de talento científico: se han conseguido 5 ayudas de recursos humanos competitivas. Además, gracias al aumento de la financiación se ha podido ampliar el personal de apoyo a la investigación que se tenía en 2021.
Dinamizar la captación de recursos: la captación de recursos ha disminuido con respecto a 2022 consiguiento 13 ayudas (3 menos que en 2022). Sin embargo, los ingresos por estudios de investigación clínica se han incrementado notablemente con respecto a 2022 (32%).

6 Grupos de Investigación

HEMATOLOGÍA Y ONCOLOGÍA MÉDICA CLÍNICO-EXPERIMENTAL (CONSOLIDADO)
CONTROL MOLECULAR DE LA PROLIFERACIÓN Y DIFERENCIACIÓN (CONSOLIDADO)
TERAPIAS MOLECULARES Y BIOMARCADORES DE TUMORES SÓLIDOS (CONSOLIDADO)
INTEGRACIÓN MORFOFUNCIONAL DE CÉLULAS Y TEJIDOS (CONSOLIDADO)
METALOFÁRMACOS ANTITUMORALES NO CONVENCIONALES (CONSOLIDADO)
PATOLOGÍA MOLECULAR Y FARMACOGENÉTICA (CONSOLIDADO)

INDICADORES GENERALES

Nº Publicaciones

543.9

Impacto Total

6.32

Impacto Medio

Tipo	Nº Pubs	FI total	FI Medio
Originales	78 (90.7%)	514.3	6.59
Revisiones	8 (9.3%)	29.6	3.7

73.26

Q1%

26.74

D1%

FI >= 15

Tipo	Nº Q1	Nº D1	Nº FI >= 15
Originales	58	23	5
Revisiones	5	0	0

INDICADORES DE LIDERAZGO

37 (43.0%)

Nº Publicaciones

176.2

Impacto Total

4.76

Impacto Medio

	Nº Pubs	FI total	FI Medio
Mujer	23 (62.16%)	116.2	5.05
Hombre	14 (37.84%)	60.0	4.29

70.27

Q1%

18.92

D1%

FI >= 15

	Nº Q1	Nº D1	Nº FI >= 15
Mujer	17	5	1
Hombre	9	2	0

OTROS INDICADORES

20.61

HCP10% (2019-2023)

48.86

HCP10 Liderado% (2019-2023)

25.0

HCP10 Lid. Mujeres% (2019-2023)

1.4

Crown (2019-2023)

76.74

Open Access%

44.19

Col. International%

* Se muestran las 5 especies, los 10 genes y las 20 enfermedades más nombradas. Los valores están normalizados logarítmicamente en base al número de publicaciones.

INDICADORES EVOLUTIVOS

DESTACADAS

Marin-Quilez A, Di Buduo CA, Diaz-Ajenjo L, ..., Rivera J et al. Novel variants in GALE cause syndromic macrothrombocytopenia by disrupting glycosylation and thrombopoiesis. Blood, 2023, 141, 406-421, PMID: 36395340, FI: 21.0

Mitjavila M, Jimenez-Fonseca P, Bello P, ..., Carmona-Bayonas A. Efficacy of [(177)Lu]Lu-DOTATATE in metastatic neuroendocrine neoplasms of different locations: data from the SEPTRALU study. European Journal of Nuclear Medicine and Molecular Imaging, 2023, 10.1007/s00259-023-06166-8 [doi], PMID: 36877234, FI: 8.6

Montenegro MF, Marti-Diaz R, Navarro A, ..., Rodriguez-Lopez JN. Targeting protein methylation in pancreatic cancer cells results in KRAS signaling imbalance and inhibition of autophagy. Cell Death & Disease, 2023, 14, 761, PMID: 37996408, FI: 8.1

Ortega-Forte E, Rovira A, Lopez-Corrales M et al. A near-infrared light-activatable Ru(ii)-coumarin photosensitizer active under hypoxic conditions. Chemical Science, 2023, 14, 7170-7184, PMID: 37416722, FI: 7.6

Zaragoza-Huesca D, Rodenas MC, Penas-Martinez J, ..., Martinez-Martinez I. Suramin, a drug for the treatment of trypanosomiasis, reduces the prothrombotic and metastatic phenotypes of colorectal cancer cells by inhibiting hepsin. Biomedicine & Pharmacotherapy, 2023, 168, 115814, PMID: 37918256, FI: 6.9

LISTADO COMPLETO

Burgos L, Tamariz-Amador LE, Puig N, ..., de Arriba F et al. Definition and Clinical Significance of the Monoclonal Gammopathy of Undetermined Significance-Like Phenotype in Patients With Monoclonal Gammopathies. Journal of Clinical Oncology, 2023, 41, 3019-3031, PMID: 36930848, FI: 42.1

Bueno-Muino C, Echavarria I, Lopez-Tarruella S, ..., Ayala de la Pena F et al. Assessment of a Genomic Assay in Patients With ERBB2-Positive Breast Cancer Following Neoadjuvant Trastuzumab-Based Chemotherapy With or Without Pertuzumab. Jama Oncology, 2023, 9, 841-846, PMID: 37103916, FI: 22.5

Rosinol L, Oriol A, Rios-Tamayo R, ..., de Arriba F et al. LENALIDOMIDE AND DEXAMETHASONE WITH OR WITHOUT IXAZOMIB MAINTENANCE TAILORED BY RESIDUAL DISEASE STATUS IN MYELOMA. Blood, 2023, blood.2022019531 [pii], PMID: 37506339, FI: 21.0

Guerrero C, Puig N, Cedena MT, ..., de Arriba F et al. Predictors of unsustained measurable residual disease negativity in transplant-eligible multiple myeloma patients. Blood, 2023, blood.2023022083 [pii], PMID: 38048552, FI: 21.0

Botta C, Perez C, Larrayoz M, ..., de Arriba F et al. Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance. Nature Communications, 2023, 14, 5825, PMID: 37730678, FI: 14.7

Muta Y, Linares JF, Martinez-Ordonez A, ..., Albaladejo-Gonzalez A et al. Enhanced SREBP2-driven cholesterol biosynthesis by PKClambda/iota deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. Nature Communications, 2023, 14, 8075, PMID: 38092754, FI: 14.7

Capdevila J, Hernando J, Teule A, ..., Carmona-Bayonas A et al. Durvalumab plus tremelimumab for the treatment of advanced neuroendocrine neoplasms of gastroenteropancreatic and lung origin. Nature Communications, 2023, 14, 2973, PMID: 37221181, FI: 14.7

Asleh K, Lluch A, Goytain A, ..., Ayala F et al. Triple-Negative PAM50 Non-Basal Breast Cancer Subtype Predicts Benefit from Extended Adjuvant Capecitabine. Clinical Cancer Research, 2023, 29, 389-400, PMID: 36346687, FI: 10.0

Harrison SP, Siller R, Tanaka Y, ..., de la Morena-Barrio ME et al. Scalable production of tissue-like vascularized liver organoids from human PSCs. Experimental and Molecular Medicine, 2023, 55, 2005-2024, PMID: 37653039, FI: 9.5

O'Callaghan E, Navarrete-Lopez P, Stiavnicka M, ..., Balastegui-Alarcon M et al. Adenylate kinase 9 is essential for sperm function and male fertility in mammals. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, e2305712120, PMID: 37812723, FI: 9.4

Martinez-Cuadron D, Megias-Vericat JE, Gil C, ..., Amigo ML et al. Outcomes after intensive chemotherapy for secondary and myeloidrelated changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry. Haematologica, 2023, 10.3324/haematol.2022.282506 [doi], PMID: 37199127, FI: 8.2

Puertas B, Gonzalez-Calle V, Sureda A, ..., Martinez-Lopez J et al. Randomized phase II study of weekly carfilzomib 70 mg/m(2) and dexamethasone with or without cyclophosphamide in relapsed and/or refractory multiple myeloma patients. Haematologica, 2023, 108, 2753-2763, PMID: 37102598, FI: 8.2

Alvarez-Larran A, Cuevas B, Velez P, ..., Ferrer-Marin F et al. Application of IPSET-thrombosis in 1366 Patients Prospectively Followed From the Spanish Registry of Essential Thrombocythemia. Hemasphere, 2023, 7, e936, PMID: 37476303, FI: 7.6

Mosquera-Orgueira A, Perez-Encinas M, Hernandez-Sanchez A, ..., Ferrer-Marin F et al. Machine Learning Improves Risk Stratification in Myelofibrosis: An Analysis of the Spanish Registry of Myelofibrosis. Hemasphere, 2023, 7, e818, PMID: 36570691, FI: 7.6

Berna-Erro A, Ramesh G, Delgado E, ..., Ferrer-Marin F et al. CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets. Arteriosclerosis Thrombosis and Vascular Biology, 2023, 43, e151-e170, PMID: 36924231, FI: 7.4

Carreno-Tarragona G, Alvarez-Larran A, Harrison C, ..., Ferrer-Marin F et al. CNL and aCML should be considered as a single entity based on molecular profiles and outcomes. Blood Advances, 2023, 7, 1672-1681, PMID: 36375042, FI: 7.4

Rovira A, Ortega-Forte E, Hally C et al. Exploring Structure-Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates. Journal of Medicinal Chemistry, 2023, 66, 7849-7867, PMID: 37265008, FI: 6.8

Novohradsky V, Marco A, Markova L et al. Ir(III) Compounds Containing a Terdentate Ligand Are Potent Inhibitors of Proliferation and Effective Antimetastatic Agents in Aggressive Triple-Negative Breast Cancer Cells. Journal of Medicinal Chemistry, 2023, 66, 9766-9783, PMID: 37410386, FI: 6.8

Martinez-Navajas G, Ceron-Hernandez J, Simon I, ..., Lozano ML et al. Lentiviral gene therapy reverts GPIX expression and phenotype in Bernard-Soulier syndrome type C. Molecular Therapy Nucleic Acids, 2023, 33, 75-92, PMID: 37416759, FI: 6.5

Perez-Wert P, Custodio A, Jimenez-Fonseca P, Carmona-Bayonas A et al. Efficacy and safety of chemotherapy in young patients with advanced gastroesophageal adenocarcinoma: data from the Spanish AGAMENON-SEOM registry. Gastric Cancer, 2023, 10.1007/s10120-023-01443-9 [doi], PMID: 37964032, FI: 6.0

Bailen R, Alenda R, Herruzo-Delgado B, ..., Lopez-Godino O et al. Results of haploidentical transplant in patients with donor-specific antibodies: a survey on behalf of the Spanish Group of Hematopoietic Transplant and Cell Therapy. Frontiers in Immunology, 2023, 14, 1165759, PMID: 37304258, FI: 5.7

Ljungman P, Tridello G, Pinana JL, ..., Heras I et al. Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry. Frontiers in Immunology, 2023, 14, 1125824, PMID: 36960069, FI: 5.7

Cruz D, Rodriguez-Romanos R, Gonzalez-Bartulos M, ..., Heras I et al. LAG3 genotype of the donor and clinical outcome after allogeneic transplantation from HLA-identical sibling donors. Frontiers in Immunology, 2023, 14, 1066393, PMID: 36742309, FI: 5.7

Zapata-Martinez L, Aguila S, de Los Reyes-Garcia AM, ..., Gonzalez-Conejero R*, Martinez C*. Inflammatory microRNAs in cardiovascular pathology: another brick in the wall. Frontiers in Immunology, 2023, 14, 1196104, PMID: 37275892, FI: 5.7

Alessi MC, Coxon C, Ibrahim-Kosta M, ..., Rivera J et al. Multicenter evaluation of light transmission platelet aggregation reagents: communication from the ISTH SSC Subcommittee on Platelet Physiology. Journal of Thrombosis and Haemostasis, 2023, 21, 2596-2610, PMID: 37331519, FI: 5.5

Zamora-Canovas A, Morena-Barrio B, Marin-Quilez A, ..., Rivera J*, Lozano ML. Targeted long-read sequencing identifies and characterizes structural variants in cases of inherited platelet disorders. Journal of Thrombosis and Haemostasis, 2023, S1538-7836(23)00844-9 [pii], PMID: 38007062, FI: 5.5

Zaninetti C, Rivera J, Vater L et al. Aggregates of non-muscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia. Journal of Thrombosis and Haemostasis, 2023, S1538-7836(23)00872-3 [pii], PMID: 38103735, FI: 5.5

Palma-Barqueros V*, Bastida JM, Lopez Andreo MJ, ..., Rivera J*. Platelet transcriptome analysis in patients with germline RUNX1 mutations. Journal of Thrombosis and Haemostasis, 2023, S1538-7836(23)00072-7 [pii], PMID: 36736831, FI: 5.5

Zaninetti C, Leinoe E, Lozano ML et al. Validation of immunofluorescence analysis of blood smears in patients with inherited platelet disorders. Journal of Thrombosis and Haemostasis, 2023, S1538-7836(23)00027-2 [pii], PMID: 36732160, FI: 5.5

de la Morena-Barrio B, Palomo A, Padilla J, ..., de la Morena-Barrio ME. Impact of genetic structural variants in factor XI deficiency: identification, accurate characterization, and inferred mechanism by long-read sequencing. Journal of Thrombosis and Haemostasis, 2023, 21, 1779-1788, PMID: 36940803, FI: 5.5

Martin A, Calvo D, Llamas P, Roldan V et al. Workplace violence in hospital emergency departments and consequences for health care professionals and support staff: a cluster analysis. Emergencias, 2023, 35, 359-377, PMID: 37801418, FI: 5.4

Zuercher P, Moser A, Garcia de Guadiana-Romualdo L et al. Discriminative performance of pancreatic stone protein in predicting ICU mortality and infection severity in adult patients with infection: a systematic review and individual patient level meta-analysis. Infection, 2023, 51, 1797-1807, PMID: 37707744, FI: 5.4

Wang YH, Yao CY, Lin CC, ..., Jerez A et al. A three-gene leukaemic stem cell signature score is robustly prognostic in chronic myelomonocytic leukaemia. British Journal of Haematology, 2023, 201, 302-307, PMID: 36746431, FI: 5.1

Carrillo-Tornel S*, Chen-Liang TH, Zurdo M, ..., Lopez AMH*, ..., Jerez A*. NOTCH1 mutation in chronic lymphocytic leukaemia is associated with an enhanced cell cycle G1/S transition and specific cyclin overexpression: Preclinical ground for targeted inhibition. British Journal of Haematology, 2023, 201, 470-479, PMID: 36573331, FI: 5.1

Natorska J, Corral J*, de la Morena-Barrio ME et al. Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype. Thrombosis and Haemostasis, 2023, 123, 880-891, PMID: 37201530, FI: 5.0

Cabrera-Serrano AJ, Sanchez-Maldonado JM, Ter Horst R, ..., Chen-Liang T et al. Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression? International Journal of Molecular Sciences, 2023, 24, PMID: 37175717, FI: 4.9

Marin-Quilez A, Diaz-Ajenjo L, Di Buduo CA, ..., Lozano ML et al. Inherited Thrombocytopenia Caused by Variants in Crucial Genes for Glycosylation. International Journal of Molecular Sciences, 2023, 24, PMID: 36982178, FI: 4.9

Pagan-Escribano J, Corral J, Minano A, ..., de la Morena-Barrio ME*. Factor XI in Carriers of Antiphospholipid Antibodies: Elevated Levels Associated with Symptomatic Thrombotic Cases, While Low Levels Linked to Asymptomatic Cases. International Journal of Molecular Sciences, 2023, 24, PMID: 38003459, FI: 4.9

Arroyo AB*, Bernal-Carrion M, Canton-Sandoval J, ..., Mulero V*. NAMPT and PARylation Are Involved in the Pathogenesis of Atopic Dermatitis. International Journal of Molecular Sciences, 2023, 24, PMID: 37175698, FI: 4.9

Cifuentes R*, Padilla J, de la Morena-Barrio ME*, ..., Corral J*. Usefulness and Limitations of Multiple Ligation-Dependent Probe Amplification in Antithrombin Deficiency. International Journal of Molecular Sciences, 2023, 24, PMID: 36902454, FI: 4.9

Gomez-Torres MJ, Luna-Romero J, Fernandez-Colom PJ, ..., Aviles M et al. Human Sperm Head Vacuoles Are Related to Nuclear-Envelope Invaginations. International Journal of Molecular Sciences, 2023, 24, PMID: 37373176, FI: 4.9

Diaz-Flores L, Gutierrez R, Gonzalez-Gomez M, ..., Madrid JF et al. Telocytes/CD34+ Stromal Cells in the Normal, Hyperplastic, and Adenomatous Human Parathyroid Glands. International Journal of Molecular Sciences, 2023, 24, PMID: 37569493, FI: 4.9

Diaz-Flores L, Gutierrez R, Gonzalez-Gomez M, ..., Madrid JF et al. Delimiting CD34+ Stromal Cells/Telocytes Are Resident Mesenchymal Cells That Participate in Neovessel Formation in Skin Kaposi Sarcoma. International Journal of Molecular Sciences, 2023, 24, PMID: 36835203, FI: 4.9

Carmona-Bayonas A*, Rodriguez-Gonzalez A, Garcia-Garcia T*, ..., Ballester I* et al. Can Oncologists Prompt Patient Prognostic Awareness to Enhance Decision-Making? Data From the Neoetic Study. Oncologist, 2023, oyad100 [pii], PMID: 37185783, FI: 4.8

Santamarina-Garcia M, Brea-Iglesias J, Bramsen JB, ..., Conesa-Zamora P et al. MSIMEP: Predicting microsatellite instability from microarray DNA methylation tumor profiles. Iscience, 2023, 26, 106127, PMID: 36879816, FI: 4.6

Garcia-Torralba E, Perez Ramos M, Ivars Rubio A, ..., Ayala de la Pena F*. Clinical Meaning of Stromal Tumor Infiltrating Lymphocytes (sTIL) in Early Luminal B Breast Cancer. Cancers, 2023, 15, PMID: 37345183, FI: 4.5

Mussetti A, Bento L, Bastos-Oreiro M, ..., Lopez-Godino O et al. Role of allogeneic hematopoietic cell transplant for relapsed/refractory aggressive B-cell lymphomas in the CART era. Bone Marrow Transplantation, 2023, 58, 673-679, PMID: 36918682, FI: 4.5

Morales ML, Ferrer-Marin F*. Deepening Our Understanding of the Factors Affecting Landscape of Myeloproliferative Neoplasms: What Do We Know about Them? Cancers, 2023, 15, PMID: 36831689, FI: 4.5

Hernandez-Garcia A, Markova L, Santana MD et al. Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis. Inorganic Chemistry, 2023, 62, 6474-6487, PMID: 37040203, FI: 4.3

Jimenez-Fonseca P, Foy V, Raby S, Carmona-Bayonas A et al. The AGAMENON-SEOM model for prediction of survival in patients with advanced HER2-positive oesophagogastric adenocarcinoma receiving first-line trastuzumab-based therapy. Therapeutic Advances in Medical Oncology, 2023, 15, 17588359231157641, PMID: 36895850, FI: 4.3

Rodenas MC, Penas-Martinez J, Pardo-Sanchez I, ..., Martinez-Martinez I*. Venetoclax is a potent hepsin inhibitor that reduces the metastatic and prothrombotic phenotypes of hepsin-expressing colorectal cancer cells. Frontiers in Molecular Biosciences, 2023, 10, 1182925, PMID: 37275957, FI: 3.9

Pinana JL, Heras I, Aiello TF et al. Remdesivir or Nirmatrelvir/Ritonavir Therapy for Omicron SARS-CoV-2 Infection in Hematological Patients and Cell Therapy Recipients. Viruses-Basel, 2023, 15, PMID: 37896843, FI: 3.8

Guarnera L, Bravo-Perez C*, Visconte V. Immunotherapy in Acute Myeloid Leukemia: A Literature Review of Emerging Strategies. Bioengineering-Basel, 2023, 10, PMID: 37892958, FI: 3.8

Asensi-Canto A, Rodriguez-Braun E, Beltran-Videla A, ..., Hurtado AM*, Conesa-Zamora P*. Effects of imipramine on cancer patients over-expressing Fascin1; description of the HITCLIF clinical trial. Frontiers in Oncology, 2023, 13, 1238464, PMID: 37841433, FI: 3.5

Marco A, Vigueras G, Busto N, ..., Ruiz J. Novel valproate half-sandwich rhodium and iridium conjugates to fight against multidrug-resistant Gram-positive bacteria. Dalton Transactions, 2023, 52, 13482-13486, PMID: 37358044, FI: 3.5

Garcia-Torralba E, Navarro Manzano E, Luengo-Gil G, ..., Ayala de la Pena F*, Garcia-Martinez E*. A new prognostic model including immune biomarkers, genomic proliferation tumor markers (AURKA and MYBL2) and clinical-pathological features optimizes prognosis in neoadjuvant breast cancer patients. Frontiers in Oncology, 2023, 13, 1182725, PMID: 37313470, FI: 3.5

Serrano-Gonzalo I, de Frutos LL, Lahoz-Gil C, ..., Labbadia F et al. Real life data: follow-up assessment on Spanish Gaucher disease patients treated with eliglustat. TRAZELGA project. Orphanet Journal of Rare Diseases, 2023, 18, 390, PMID: 38102667, FI: 3.4

Paredero-Perez I, Jimenez-Fonseca P, Cano JM, ..., Carmona-Bayonas A et al. State of the scientific evidence and recommendations for the management of older patients with gastric cancer. Journal of Geriatric Oncology, 2023, , 101657, PMID: 37957106, FI: 3.0

Leou K, Mendez D, Horani G, ..., Garcia de Guadiana-Romualdo L et al. Effects of Etomidate on Postintubation Hypotension, Inflammatory Markers, and Mortality in Critically Ill Patients with COVID-19: An International, Multicenter, Retrospective Study. Journal of Intensive Care Medicine, 2023, 38, 922-930, PMID: 37151026, FI: 3.0

Castillo MI, Ribate VE, Munoz CM, ..., Cayuela JA* et al. Incidence and prognostic impact of U2AF1 mutations and other gene alterations in myelodysplastic neoplasms with isolated 20q deletion. Cancer Medicine, 2023, 12, 16788-16792, PMID: 37403747, FI: 2.9

Rodenas-Quinonero I, Chen-Liang T, Martin-Santos T, ..., Ortuno FJ*. Accuracy and prognostic impact of FDG PET/CT and biopsy in bone marrow assessment of follicular lymphoma at diagnosis: A Nation-Wide cohort study. Cancer Medicine, 2023, 12, 6536-6546, PMID: 36373169, FI: 2.9

Sanchez-Canovas M, Jimenez-Fonseca P, Fernandez Garay D, ..., Carmona-Bayonas A. Prediction of serious complications in patients with pulmonary thromboembolism and solid cancer: Validation of the EPIPHANY Index in a prospective cohort of patients from the PERSEO study. Plos one, 2023, 18, e0266305, PMID: 37159465, FI: 2.9

Ayala de la Pena F*, Antolin Novoa S, Gavila Gregori J et al. SEOM-GEICAM-SOLTI clinical guidelines for early-stage breast cancer (2022). Clinical & Translational Oncology, 2023, 25, 2647-2664, PMID: 37326826, FI: 2.8

Castillon JC, Gordoa TA, Bayonas AC et al. SEOM-GETNE clinical guidelines for the diagnosis and treatment of gastroenteropancreatic and bronchial neuroendocrine neoplasms (NENs) (2022). Clinical & Translational Oncology, 2023, 25, 2692-2706, PMID: 37204633, FI: 2.8

Vera R, Juan-Vidal O, Safont-Aguilera MJ, de la Pena FA et al. Sex differences in the diagnosis, treatment and prognosis of cancer: the rationale for an individualised approach. Clinical & Translational Oncology, 2023, 25, 2069-2076, PMID: 36802013, FI: 2.8

de Los Reyes-Garcia AM*, Zapata-Martinez L, Aguila S, ..., Martinez C*, Gonzalez-Conejero R*. microRNAs as biomarkers of risk of major adverse cardiovascular events in atrial fibrillation. Frontiers in Cardiovascular Medicine, 2023, 10, 1135127, PMID: 36895835, FI: 2.8

Rodriguez-Gonzalez A, Carmona-Bayonas A, Hernandez San Gil R et al. Impact of systemic cancer treatment on quality of life and mental well-being: a comparative analysis of patients with localized and advanced cancer. Clinical & Translational Oncology, 2023, 10.1007/s12094-023-03214-5 [doi], PMID: 37247131, FI: 2.8

Medina I, Carpio C, Ruiz-Camps I, ..., Lopez-Godino O et al. Adenovirus-induced hemorrhagic cystitis after CD19-targeted chimeric antigen receptor T-cell therapy in a patient with large B-cell lymphoma. Immunotherapy, 2023, 10.2217/imt-2023-0111 [doi], PMID: 37718888, FI: 2.7

Valcarcel S, Gallego J, Jimenez-Fonseca P, ..., Carmona-Bayonas A. Does HER2 status influence in the benefit of ramucirumab and paclitaxel as second line treatment of advanced gastro-esophageal adenocarcinoma? Data from the AGAMENON-SEOM registry. Journal of Cancer Research and Clinical Oncology, 2023, 149, 4077-4089, PMID: 36042046, FI: 2.7

Gomez-Torres MJ, Huerta-Retamal N, Saez-Espinosa P, ..., Aviles M et al. Molecular Chaperone HSPA2 Distribution During Hyaluronic Acid Selection in Human Sperm. Reproductive Sciences, 2023, 30, 1176-1185, PMID: 35819578, FI: 2.6

Marin-Quilez A, Di Buduo CA, Benito R, ..., Rivera J* et al. GALE variants associated with syndromic manifestations, macrothrombocytopenia, bleeding, and platelet dysfunction. Platelets, 2023, 34, 2176699, PMID: 36846897, FI: 2.5

Sanchez-Villalobos JM*, Serna-Berna A, Salinas-Ramos J, ..., Alcaraz M* et al. Volumetric Modulated Arc Therapy for Radiosurgery of Brain Metastases: A Single-Center Study Applied Sciences-Basel, 2023, 13, PMID: null, FI: 2.5

Diaz-Flores L, Gutierrez R, Pino Garcia M, ..., Madrid JF et al. Intussusceptive angiogenesis facilitated by microthrombosis has an important example in angiolipoma. An ultrastructural and immunohistochemical study. Histology and Histopathology, 2023, 38, 29-46, PMID: 35775452, FI: 2.5

Lee EM, Jimenez-Fonseca P, Carmona-Bayonas A et al. Clinicians' and Advanced Cancer Patients' Estimates of Treatment Efficacy and Toxicity in Oncologic Treatment. Healthcare, 2023, 11, PMID: 37570462, FI: 2.4

Bravo-Perez C*, Guarnera L, Williams ND et al. Paroxysmal Nocturnal Hemoglobinuria: Biology and Treatment. Medicina-Lithuania, 2023, 59, PMID: 37763731, FI: 2.4

Torrent A, Morgades M, Garcia-Calduch O, ..., Lopez-Godino O et al. Results of the compassionate program of inotuzumab ozogamicin for adult patients with relapsed or refractory acute lymphoblastic leukemia in Spain. European Journal of Haematology, 2023, 111, 485-490, PMID: 37381686, FI: 2.3

Ferra Coll C, Morgades de la Fe M, Prieto Garcia L, ..., Lopez-Godino O et al. Prognosis of patients with acute lymphoblastic leukaemia relapsing after allogeneic stem cell transplantation. European Journal of Haematology, 2023, 110, 659-668, PMID: 36813736, FI: 2.3

Cerezo Manchado JJ, Iturbe Hernandez T, Martinez Pacheco MDC et al. Impact of New Onset Atrial Fibrillation in Hospitalized Patients with COVID-19. Results of the "ACO-VID" Registry. Clinical and Applied Thrombosis-Hemostasis, 2023, 29, 10760296231208440, PMID: 37899606, FI: 2.3

Calleja JL, Delgado Sanchez O, Fuentes Pradera MA, ..., Lozano ML et al. Recommendations for the future management of thrombocytopenia in patients with liver cirrhosis: A modified RAND/UCLA appropriateness method. Gastroenterologia y Hepatologia, 2023, S0210-5705(23)00072-9 [pii], PMID: 37028757, FI: 2.2

Hernandez-Caravaca I, Moros-Nicolas C, Gonzalez-Brusi L, ..., Izquierdo-Rico MJ. Colostrum Features of Active and Recovered COVID-19 Patients Revealed Using Next-Generation Proteomics Technique, SWATH-MS. Children-Basel, 2023, 10, PMID: 37628421, FI: 2.0

Moros-Nicolas C, Lopez-Ubeda R, Luongo C, ..., Garcia-Vazquez FA*. Boar sperm motility is modulated by CCK at a low concentration of bicarbonate under capacitation conditions. Reproduction in Domestic Animals, 2023, 58, 1164-1171, PMID: 37332097, FI: 1.6

AYUDAS CONCEDIDAS EN 2023

TOTAL DE AYUDAS CONCEDIDAS

Nº Ayudas

1.19M €

Financiación

TOTAL DE AYUDAS RECURSOS HUMANOS CONCEDIDAS

Nº Ayudas

0.31M €

Financiación

TOTAL DE AYUDAS PROYECTOS I+D+i CONCEDIDAS

Nº Ayudas Europeas

0.01M €

Financiación Europea

Nº Ayudas Nacionales

0.78M €

Financiación Nacional

Nº Ayudas Regionales

0.07M €

Financiación Regional

TOTAL DE REDES CONCEDIDAS

Nº Ayudas

0.0M €

Financiación

OTRAS AYUDAS COMPETITIVAS CONCEDIDAS (MOVILIDAD, ORGANIZACIÓN DE EVENTOS CIENTÍFICOS, ...)

Nº Ayudas

20.47K €

Financiación

PROYECTOS DE I+D+i Y AYUDAS DE RRHH ACTIVAS EN 2023

TOTAL AYUDAS

RECURSOS HUMANOS

REDES

PROYECTOS INTERNACIONALES

PROYECTOS NACIONALES

PROYECTOS REGIONALES

INICIADA EN 2023

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

ACTIVOS EN 2023

117

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

FACTURACIÓN EN 2023

0.53M €

Facturado

Nº Tesis (4 con mención internacional)